Before you try something complicated, you should perform some basic troubleshooting operations.
Restart your computer.
Clean the dirt of the mouse wheel.
Connect your mouse to another USB port of the computer if possible.
Replace the mouse batteries if you are using a wireless mouse. This is because old batteries can give rise to irregular behaviors.
In another program like Notepad or Word, try scrolling the mouse to have a check.
Disable Certain Mouse Scrolling Features
If you are using a Microsft mouse, you may find many features in the Microsoft Mouse and Keyboard Center. They are problematic when it comes to the issue of mouse wheel scrolling wrong way.
As it turns out, disabling some features can be helpful to fix the issue of the mouse wheel not scrolling smoothly. Do as follows:
Open Control Panel via the search bar in Windows 10 and let Windows display all the items by large icons.
Click the Mouse link to open the Mouse settings window.
Go to Change Mouse Wheel Settings > Change Microsoft Mouse Settings to open the Microsoft Mouse and Keyboard Center.
Under the Basic Settings tab, disable Accelerated Vertical Scrolling and Reverse Scroll Direction.
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